A dazzling triumph from the bestselling author of The Virgin Suicides, Middlesex is the astonishing tale of a gene that passes down through three generations of a Greek American family and flowers in the body of Calliope Stephanides.

"I was born twice: first, as a baby girl, on a remarkably smogless Detroit day in January of 1960; and then again, as a teenage boy, in an emergency room near Petoskey, Michigan, in August of 1974."

So begins Jeffrey Eugenides' second novel, Middlesex, the story of Calliope Stephanides, who discovers at the age of fourteen that she is really a he. Cal traces the story of his transformation and the genetic condition that caused it back to his paternal grandparents, who happen also to be brother and sister, and the Greek village of Bithynios in Asia Minor.

In 1922, Desdemona Stephanides and her brother, Lefty, whose parents were killed in the recent war with the Turks, are living alone in their nearly abandoned village. Pulled together by isolation, sympathy, and, perhaps, fate, Lefty and Desdemona become husband and wife, and a recessive genetic condition begins its journey toward eventual expression in their grandchild Calliope.

Middlesex is a story about what it means to occupy the complex and unnamed middle ground between male and female, Greek and American, past and present. For Cal, caught between these identities, the journey to adulthood is particularly fraught. Jeffrey Eugenides' epic portrayal of Cal's struggle is classical in its structure and scope and contemporary in its content; a tender and honest examination of a battle that is increasingly relevant to us all.