Early eighteenth-century London, and two doctors are crisscrossing the boundaries of morality in the heady pursuit of scientific progress. This challenge leads Sir Edmund Calcraft, an eminent and notorious anatomist, and Joseph Bendix, his ambitious young student, into playing a dark game with the lawless side of English society. But Bendix&'s growing passion for a woman he first glimpses in Calcraft&'s house threatens to end their mutual quest.

From gallows to madhouses, from anatomical laboratories to a Frost Fair set on the frozen Thames, the two men compete in both head and heart. Mixing history, medical lore, and myth, The House of Sight and Shadow is a compelling tale about ambition, deception, and the fallibility of both love and reason.