And Sometimes Why takes a magnifying glass to the choices that define a life, and the twists of fate that can rearrange them. Specifically, how a traffic accident triggers a chain of events that upends the lives of a disparate group of people living in Los Angeles. In that one moment, a colorful spectrum of characters emerges: Harry Harlow, a TV game show host with a dwindling career and a passion for something to believe in beyond the gilt Hollywood façade; Anton, a novice filmmaker who fancies himself the Next Big Thing, despite his unemployment; and Misty, who is falling lower in the ranks of young actresses who are perhaps selling more than their souls to make it in LA.